(Note: Read Part 3a of the series before reading this post)
Viruses
The HIV virus mutates at the evolutionary speed limit: 10,000 times faster than most cells such as malaria.[1] And its genome is rather small (nine genes versus thousands in malaria).[2] Its small size combined with a short generation time (1-2 days) and super-rapid mutation rate means every single nucleotide in the HIV genome will mutate 10,000 to 100,000 times in every infected person every day, and thus double point mutations like the one that made malaria immune to Chloroquine occur in every person every day. In fact, over the past several decades every possible combination of up to six point mutations has occurred in HIV somewhere in the world. If RM drives macroevolutionary changes in organisms, then we should observe macroevolution in the HIV virus since it experiences more mutations than any other organism. But we don’t. HIV has run the gamut of all possible mutations to its genome, and yet with all of these mutations in a population of 100 billion billion viruses, no new cellular machinery has been created, and no new organism has developed! HIV is still HIV. It still contains the same number of proteins, still performs the same function, and still binds to its host the same way it always has. There have been no significant biochemical changes. Even gene duplication has failed to produce any new biological information.
After observing trillions upon trillions of microorganisms over thousands upon thousands of generations we have discovered that RM has achieved very little in the way of biochemical advancement, and hence evolutionary significance. If RM cannot produce macro-evolutionary changes in bacteria, parasites, or viruses with their huge population sizes and short generation times, then surely there is no reason to think RM can do more in multi-cellular, di-sexual organisms such as mammals whose population sizes are orders of magnitude smaller, with generation times hundreds and thousands of times longer. As geneticist Francois Jacob said, evolution is a tinkerer, not an engineer. By tinkering around with a genome RM may get lucky and produce some functional advantage for an organism that helps it survive, but it does so at the expense of breaking existing biological information. While burning biological bridges may be functionally advantageous for stopping the advancement of the enemy, and hence one’s survival, it is of no help in building new cellular machinery. As physicist Lee Spetner noted, “Whoever thinks macroevolution can be made by such mutations is like the merchant who lost a little money on every sale but thought he could make it up on volume.”[3] The biochemical engineering needed to originate new kinds requires the aid of an Intelligent Engineer, not a blind tinkerer.
Conclusion
The scientific evidence is not confirming the neo-Darwinian synthesis, but falsifying it. The empirical evidence points to the regular involvement of an Intelligent Designer in the history of life. If modern science had not committed itself to the philosophy of methodological naturalism (in which only naturalistic explanations are allowed for natural phenomenon) Darwinism would be laughed out of court for paucity of evidence.
Darwinism has prevailed, not because it is the best explanation of the data, but because it is the best naturalistic explanation of the data – the only kind of explanation many scientists are willing to consider based on their a priori commitment to naturalism. If one begins by assuming philosophical or methodological naturalism, then something like Darwinism has to be true even in the absence of evidential confirmation and explanatory value. As Richard Dawkins has admitted, “Even if there were no actual evidence in favor of the Darwinian theory…we should still be justified in preferring it over all rival theories.”[4] (emphasis mine) Why? Because Darwinism is a naturalistic theory, while others are not. Darwinism wins the day, not because it has prevailed over the competition, but because it has eliminated the competition by definitional fiat, rooted in a philosophical bias. When you define your league so narrowly that only one team is allowed to play, is it any surprise that you win the World Series?
The question that scientists need to ask themselves – and that you need to ask yourself – is what the goal of science is. Is the goal to find the right answers, or the right kind of answers; i.e. philosophically acceptable ones? I think Greg Koukl answers this question best: “The object and domain of science should be the physical world, but its goal should be truth, not merely physical explanations. Though science is restricted to examining physical effects, when causes are inferred, there should be no limitation.”[5] The goal of science should be discovering the truth about physical reality, and if the evidence points to the involvement of an intelligent agent, then so be it. Indeed, that is where the evidence points, and it does so with a neon sign.
For previous posts, see parts 1, 2, 3a)
[1]On average, a new mutation will occur every time a copy of the virus is made. Compare this to human beings. Though our genome is 1,000,000 times larger than HIV’s, the typical human being will only experience 1 mutation over the course of an entire lifetime, and trillions upon trillions of copies.
[2]Its genome is less than 1/1000th the size of the malaria genome, and 1/1,000,000th the size of the human genome.
[3]Physicist Lee Spetner, Not by Chance! Shattering the Modern Theory of Evolution (Brooklyn, NY: The Judaica Press, 1997).
[4]Richard Dawkins, The Blind Watchmaker (New York: Norton, 1986), 287.
[5]Greg Koukl, Solid Ground, July/Augusts 2005 issue, 3.
April 21, 2010 at 4:48 pm
You think gene duplication doesn’t matter?
http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0020207
Here’s the punchline.
“We identified 1,005 genes, either as isolated genes or in clusters positionally biased toward rearrangement-prone genomic regions, that produced relative hybridization signals unique to one or more of the hominoid lineages. Measured as a function of the evolutionary age of each lineage, genes showing copy number expansions were most pronounced in human (134) and include a number of genes thought to be involved in the structure and function of the brain. “
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April 22, 2010 at 11:05 am
This isn’t the post in which I discussed gene duplication, but I’ll respond anyway.
I don’t see how your quote proves anything. All it proves is that evolutionists think gene duplication is responsible for new biological information. That’s obvious. What they don’t show is how this is possible; i.e. a testable biological pathway.
The question is how gene duplication can supply new information. By itself, it can’t. It must undergo new mutations to become new information. And I demonstrated how this is beyond the realm of chance for three reasons:
1. The entire gene would have to remain functional with each mutation
2. It would require a lot of mutations
3. No deleterious mutations are permitted
Since your comment on this issue doesn’t appear under the post discussing it, let me repeat it again:
“It is highly unlikely that all point mutations will be beneficial. Consider something as simple as HTML code. If one randomly inserts, inverts, and deletes various characters in the code, what are the chances that every change will be beneficial? The chances are extremely low. The chances are overwhelmingly greater that most changes will be deleterious to the integrity and function of the code. Likewise, as soon as one or more harmful mutations accumulate in a critical region of the gene, the gene will either cease to function or function sub-optimally, affecting the organism’s fitness. And because energy is required to preserve this broken gene in subsequent generations, the organism’s overall fitness will decrease, or natural selection will eliminate the broken gene.
“But what if – by chance – every mutation was a beneficial one? Over time, couldn’t the gene evolve to form new genetic information? Apart from the extremely unlikely possibility that the duplicate gene would experience beneficial – and only beneficial mutations – is it reasonable to think new genetic information could be gained through such a process? No, because the gene would need to remain functional throughout the evolutionary process (i.e. it must always convey a biologically functional message) if it is to provide a survival advantage to the organism nature can select for. How could this be done by changing one nucleotide at a time? While small amounts of information could conceivably maintain function while undergoing slight, successive evolutionary changes, it is inconceivable that the same could happen for large amounts of biological information. For example, we could evolve WORD into GENE one letter at a time and preserve meaning throughout the process:
WORD
WORE
GORE
GONE
GENE
“But what if we had to evolve ‘gene duplication does not provide additional genetic information’ into ‘we have to consider the fact that double point mutations are highly improbable’ one letter at a time? How could the sentence retain some comprehensible meaning throughout the evolutionary process? It is impossible, and my analogy only contains 66 characters. Most genes contain hundreds of genetic characters! And yet for macroevolution to occur, this process would need to repeat itself millions of times over.”
Jason
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April 22, 2010 at 12:37 pm
“What they don’t show is how this is possible; i.e. a testable biological pathway.”
Did you read the paper in its entirety? If you do this, I think you’ll see how gene duplication can “add information”. My advice is to read the paper.
By the way, can you define “new information”. What exactly are we looking for here? What would you accept as “new information”.
“And I demonstrated how this is beyond the realm of chance for three reasons.
1. The entire gene would have to remain functional with each mutation
2. It would require a lot of mutations
3. No deleterious mutations are permitted”
I’m afraid that these “three reasons” and your HTML example suggest that you don’t really have a good grasp of molecular genetics, specifically, or biology and evolution, in general. May I ask…what is your academic background with respect to evolution and genetics? Have you read any of Sean Carroll’s books on genetics and evolutionary developmental biology?
I’m not sure that you understand how things work in the biological world.
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April 22, 2010 at 2:50 pm
Philip,
No, I didn’t read it. I read the abstract you quoted, and saw nothing to contradict the evidence I have presented. And I don’t have time to read every paper anyone chooses to point me to on this blog. If there is relevant evidence in the paper, then summarize the evidence for me and I will respond. But don’t give me the, “So-and-So disagrees, so you must be wrong” routine. We can both point to So-and-Sos who agree with our position. The question is what their evidence is. I presented my evidence in the blog posts. What is yours?
Biological information conveys “directions” for cell operation. It specifies what to make, how to make it, and how to use it. If you want a new biological function, you need additional biological information. How does one get that? Evolutionists say it happens via mutation. I examined this possibility both conceptually and empirically and demonstrated that mutations can only produce small changes in species, not new species. Please explain to me how mutation can be responsible for producing thousands of major structural/biological innovations in mammals, when it can’t even create a single new protein in micro-organisms? Micro-organisms experience more mutations in just a few decades than all mammals have experienced throughout their entire history. How is it that mammals came to evolve thousands of new systems and very diverse anatomies when micro-organisms, which experience many more mutations, haven’t been observed to build a single new protein, system, or species? Random mutation has been tested and been shown as wholly inadequate for producing new species. You have to account for that data rather than point our attention elsewhere.
Jason
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April 22, 2010 at 7:28 pm
“Micro-organisms, which experience many more mutations, haven’t been observed to build a
single new protein, system or species.”
Define “new protein”. Define “species” with respect to micro-organisms. Unless you know what would constitute a new gene or new protein or new species, how do you know what has or hasn’t been observed? (And I’m still looking for a definition for “new information”.)
Once you have definitions for the above terms, you can apply those defintion in the context of the following:
http://www.nature.com/nchembio/journal/v5/n8/full/nchembio.197.html
“I don’t have time to read every paper anyone chooses to point me to on this blog.”
So, what am I supposed to do with someone who won’t examine and/or can’t understand the evidence? Let’s be honest. You didn’t read this paper, because you lack the background to understand it.
“I examined this possibility both conceptually and empirically and demonstrated that mutations can only produce small changes in species, not new species….Please explain to me how mutation can be responsible for producing thousands of major structural/biological innovations in mammals, when it can’t even create a single new protein in micro-organisms?”
I’m sorry, but I see little evidence that you are familiar with this subject. Can you you list the books that you’ve read that have been written by evolutionary biologists? Ever taken a course in molecular genetics or developmental biology? Again, have you read anything by Sean Carroll, a biologist who writes extenstively about evolution, developmental biology and genetics? Read Carroll’s books, and you’ll have your explanation.
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April 23, 2010 at 4:09 am
Can you you list the books that you’ve read that have been written by evolutionary biologists? Ever taken a course in molecular genetics or developmental biology?
Goldilocks Syndrome is about to rear its persnickety head. Nothing you cite or relate will suffice.
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April 23, 2010 at 8:38 am
Goldilocks Syndrome is about to rear its persnickety head. Nothing you cite or relate will suffice.
Wha…?
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April 23, 2010 at 1:13 pm
Goldilocks Syndrome says that since your mind is made up concerning this subject, nothing cited or related to you which contradicts the a priori commitment you have to naturalism will suffice. You ask for a list of books by evolutionary biologist (read – books written by biologist with the same i>a priori commitment) which necessarily eliminates the very book written by a molecular biologist Jason is busily reviewing.
All of this hullabaloo is right after you commit the Genetic fallacy in this statement “I’m sorry, but I see little evidence that you are familiar with this subject.” Jason had just asked the question, “Please explain to me how mutation can be responsible for producing thousands of major structural/biological innovations in mammals, when it can’t even create a single new protein in micro-organisms?” That question is either valid or it isn’t and if it is valid, it deserves an answer. Jason’s credentials are irrelevant to the question.
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April 23, 2010 at 1:51 pm
“Goldilocks Syndrome says that since your mind is made up concerning this subject, nothing cited or related to you which contradicts the a priori commitment….”
Everything I’ve read here sugggests that Jason’s mind is made up, too. And are you going to tell me that your mind is not made up? Did you read the articles that I linked to? So pot…kettle…black.
“You ask for a list of books by evolutionary biologist…”
Yes, because whether there are “a priori commitments” or not, you need to read these books to understand the subject. Understanding anything in science requires a knowledge base. In this case, books written by evolutionary biologists provide an essential knowledge base for the subject under discussion. If we were discussing any other subject in science, wouldn’t it be reasonable to expect that the participants in the discussion would have read the writings of the leading scientists in the field? Name one field of science in which one should not read books written by the scientists working in that field?
Jason keeps asking questions and/or making inaccurate statements about a variety of subjects, and answers and/or corrections are available if one would just do a little reading! It’s extraordinary to me that one would put up numerous posts about evolution, molecular genetics, etc., without first learning the subject. It’s ok to not know much about something, but if one is going to comment at length on one’s blog about a subject, don’t you think that it’s important to be informed about the subject? You don’t need a “commitment to naturalism” to understand molecular genetics or developmental biology, but you do have to take the time to educate yourself about these fields, especially if your going to lead with your chin. By the way, there are plenty of books explaining evolution that are written by Christians.
“Jason had just asked the question, “Please explain to me how mutation can be responsible for producing thousands of major structural/biological innovations in mammals, when it can’t even create a single new protein in micro-organisms?” That question is either valid or it isn’t and if it is valid, it deserves an answer.”
First, the question is not valid, because we have no definition of “new protein”. How can one make an observation when one doesn’t know what one is looking for?
Nevertheless, after guessing what Jason means when he uses the word “new”, I provided an answer with the following link. This article discusses the evolution of new metabolic pathways that require new genes. Yes, mutation can produce new proteins.
http://www.nature.com/nchembio/journal/v5/n8/full/nchembio.197.html
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April 25, 2010 at 9:48 am
Jason,
I don’t know about “Goldilocks” but I do believe that he had a point on one thing. It’s important to read both sides, not just your side’s portrayal of the other side. Familiarity with strawmen isn’t the same as familiarity with the other side.
Arthur
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April 30, 2010 at 3:17 pm
Philip,
I’m pressed for time, but let me respond to your question about my credentials and background.
I do not have a problem with someone asking me for my knowledge background, but I do have a problem when that question is asked in lieu of providing answers to specific questions.
And providing links to other sites is not a rebuttal. I don’t have time to read every article/site/book every person thinks I should read. If you think these sources refute my argument, then summarize those arguments for me so I can interact with them.
Am I a scientist? No. Are you? Do you have a Ph.D. in molecular biology? If you don’t, should I dismiss your arguments? Of course not. What matters is whether the arguments are sound and based on accurate empirical data. The claims I made in the post were not from some experiments I ran in my back yard. They are based on empirical data that I have learned from those who specialize in the field. If their facts are wrong, then point that out. But it won’t do any good to question my credentials because I am not the source of this information. I am just summarizing the biological facts, and commenting on their importance to the Darwinism vs. Intelligent Design debate.
Do you mean to say that anyone lacking a PhD in this field shouldn’t be thinking and writing about it? If so, then why do your fellow PhD guys like Carroll write books on the topic aimed at common folks like me to persuade them toward Darwinism? If one has to be a specialist in the field to properly understand it, then they shouldn’t be writing books for the lay person. But they do. So why can’t guys with PhDs in this field write books aimed at common folks like me to persuade me against Darwinism and toward ID? And why shouldn’t a commoner like me be able, after reading them, to write about the arguments?
The bottom line is that this is a red herring. If my facts are wrong, just prove it with relevant facts. If my assessment of the facts is wrong, again, provide an argument. You’ve spent a lot of time talking about my ignorance, but not much time demonstrating it. By all means, demonstrate it. And I’m not being facetious. If I’m wrong, I’d like to see where.
Jason
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April 30, 2010 at 5:23 pm
“I don’t have time to read every article/site/book every person thinks I should read.”
You obviously had time to read Behe’s book. The articles I linked to were much, much shorter than that. Why not take a little more time to read the articles?
“What matters is whether the arguments are sound and based on accurate empirical data.”
And how are you, personally, going to figure out if a given argument is sound and based on accurate empirical data if you have no understanding of the subject?
“And why shouldn’t a commoner like me be able, after reading them, to write about the arguments?”
Feel free to do so, but why not do so after you’ve read some books written by evolutionary biologists? Yes, Carroll writes books aimed at common folks, so why not take advantage of this? Then move on to Shubin, Miller and Coyne.
As to showing you where you are wrong, as I’ve said before, first we need definitions. Define new gene, new protein, and new information.
Oh, and yeah, I have a PhD in science.
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April 30, 2010 at 5:32 pm
Now, if you really don’t have time to read links to other sites, then don’t google the phrase “evolution of new genes”. You’ll get 55,600 hits.
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May 1, 2010 at 10:20 am
Jason,
One problem with summarizing somebody else’s argument into 1-2 lines is that it can be easily misunderstood.
Arthur
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